07.09.2021

Scientist - Protein manufacturing

Precirix, incorporated in 2014 as a spin-off company of Vrije Universiteit Brussel (VUB), develops novel targeted radiopharmaceuticals using camelid single domain antibody fragments labeled with radioisotopes.

The company’s lead product CAM-H2, a new treatment option in HER2-positive cancers, is in early clinical development. The pipeline further consists of two pre-clinical programs leveraging the technology strengths. For the expansion of our Protein Science team based in Brussels, we are currently looking for an enthusiastic and talented Scientist.

Purpose of the Position:

Contribute to the development, manufacturing and characterization of camelid single-domain antibodies (sdAbs) to feed the company’s clinical pipeline of targeted radionuclide therapeutics.

As Protein Manufacturing Scientist you will manage and execute Protein Manufacturing projects, that contribute to the drug product manufacturing. The projects focus on the following R&D themes and CMC aspects:

  • sdAb manufacturing process development and characterization (strain development, USP, DSP)
  • sdAb analytics development (IPC, QC, characterization)
  • sdAb characterization

Key Responsibilities

Scientific activities

  • Responsible to originate, plan and perform research activities within the scope of an assigned work package and timing
  • Collaborate with subcontractors
  • Develop and implement new analytical methods
  • Suggest new methodologies and approaches
  • Act as a subject matter expert in CMC aspects of protein manufacturing and characterization (science and methodology)
  • Conduct experiments and contribute to the good functioning of the lab
  • Independently interpret, document, retain and summarize raw data and results in adequate systems (e.g. lab notebooks)

Project support

  • Report about data and results to the R&D leadership and in R&D team meetings
  • Active in multiple projects inside the company

Communication

  • Report about progress and conclusions of work packages
  • Prepare written reports, summaries, manuscripts and other documents as appropriate

Skills, Expertise and Contribution

  • Relevant experience in molecular biology is a must
  • Experience in upscaling a recombinant protein manufacturing process (USP, DSP) from lab scale to clinical scale, or analytical characterization of the recombinant protein is a plus
  • Keep abreast with relevant scientific and/or technical developments. Search literature and other sources independently and apply knowledge on the job
  • Work independently within the scope of assigned field and support others
  • Self-organized and a team player
  • Good communication skills (written and orally)
  • Can deal with significant responsibilities and is stress-resistant

Minimum Qualifications

  • Expected educational qualifications: PhD or MSc with equivalent experience in a relevant field of life sciences (Bio-engineering sciences, Biochemistry, Biology, Biomedical sciences).


Want to explore this opportunity? Mail us at jobs@precirix.com with a letter of motivation and your cv; and we will get in touch with you

Your browser is not supported. Update your browser for more security, speed and to make the most of this site.