31.05.2022

Research Associate - Protein CMC

Precirix is a clinical-stage biopharmaceutical company dedicated to extending and improving the lives of cancer patients by designing and developing novel radiopharmaceuticals, using camelid-derived single-domain antibodies (sdAb) labeled with radioisotopes. The company’s lead product, CAM-H2, is being evaluated in a Phase I/II trial targeting metastatic HER2-positive cancer. In addition, the company has two product candidates in preclinical stage and is further broadening its platform through research on new targets, different isotopes, linker technology and combination therapies.

For the expansion of our Protein R&D team based in Brussels, we are currently looking for an enthusiastic and talented Research Associate to work in our new laboratories starting from September.


Purpose of the Position:

As Research Associate Protein CMC you will contribute to the development, manufacturing and characterization of camelid single-domain antibodies (sdAbs) to feed the company’s preclinical and clinical pipeline of targeted radionuclide therapeutics.

You will be involved in projects that focus on the development, upscaling and characterization of processes for (clinical) sdAb manufacturing and conjugation (strain development, USP, DSP, formulation). Also, you will contribute to analytical assay development (IPC, QC) and sdAb characterization.

Key Responsibilities

Scientific activities

  • Perform research activities within the scope of an assigned work package and timing, under direct supervision of experienced scientists
  • Conduct experiments in manufacturing process development, upscaling and characterization
  • Contribute to the good functioning of the lab
  • Active in multiple projects inside the company
  • Independently interpret, document, retain and summarize experimental data and results in adequate systems (e.g. electronic lab notebooks and databases)

Communication

  • Report (written and orally) about progress and conclusions of work packages to the R&D leadership team
  • Report experimental data and results during recurring R&D team meetings
  • Prepare written reports, summaries, manuscripts and other documents as appropriate

Skills, Expertise and Contribution

  • Relevant experience in molecular biology is a must
  • Experience in upscaling a recombinant protein manufacturing process (USP, DSP) from lab scale to clinical scale, and/or analytical characterization of the recombinant protein is a plus
  • Keep abreast with relevant scientific and/or technical developments. Search literature and other sources independently and apply knowledge on the job
  • Work independently within the scope of assigned work package and support others
  • Attentive to details and quality-oriented
  • Thrives in a multi-disciplinary team environment
  • Self-organized and a team player
  • Good written and oral communication skills
  • Show flexibility in your work and being stress-resistant

Qualifications

  • Expected educational qualifications: MSc or BSc with equivalent experience in a relevant field of life sciences (Bio-engineering sciences, Biochemistry, Biology, Biomedical sciences).

Want to explore this opportunity? Mail us at jobs@precirix.com with a letter of motivation and your cv; and we will get in touch with you.

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